North America Active Pharmaceutical Ingredients (API) Market 2021-2028 by Synthesis (Synthetic, Biotech, HPAPI), Manufacturing Process (Captive, Merchant), Therapeutic Application, Drug Type, and Country: Trend Forecast and Growth Opportunity

1.1 Industry Definition and Research Scope 9

1.1.1 Industry Definition 9

1.1.2 Research Scope 10

1.2 Research Methodology 13

1.2.1 Overview of Market Research Methodology 13

1.2.2 Market Assumption 14

1.2.3 Secondary Data 14

1.2.4 Primary Data 14

1.2.5 Data Filtration and Model Design 15

1.2.6 Market Size/Share Estimation 16

1.2.7 Research Limitations 17

1.3 Executive Summary 18

2 Market Overview and Dynamics 20

2.1 Market Size and Forecast 20

2.1.1 Impact of COVID-19 on World Economy 21

2.1.2 Impact of COVID-19 on the Market 23

2.2 Major Growth Drivers 30

2.3 Market Restraints and Challenges 38

2.4 Emerging Opportunities and Market Trends 41

2.5 Porter’s Fiver Forces Analysis 45

3 Segmentation of North America Market by Synthesis 49

3.1 Market Overview by Synthesis 49

3.2 Synthetic API 51

3.2.1 Branded Synthetic API 52

3.2.2 Generic Synthetic API 53

3.3 Biotech API 54

3.3.1 Biotech API by Drug Type 55

3.3.1.1 Monoclonal Antibodies 56

3.3.1.2 Recombinant Proteins 57

3.3.1.3 Vaccines 58

3.3.1.4 Other Biotech APIs 59

3.3.2 Biotech API by Category 60

3.3.2.1 Innovative Biologic API 61

3.3.2.2 Generic Biosimilar API 62

3.3.3 Biotech API by Expression Technology 63

3.3.3.1 Mammalian Expression 64

3.3.3.2 Microbial Expression 65

3.3.3.3 Yeast Expression 66

3.3.3.4 Insect Expression 67

3.3.3.5 Other Expression Technologies 68

3.4 HPAPI 69

3.4.1 Branded HPAPI 70

3.4.2 Generic HPAPI 71

4 Segmentation of North America Market by Manufacturing Process 72

4.1 Market Overview by Manufacturing Process 72

4.2 Captive Manufacturing 74

4.2.1 Branded Captive API 75

4.2.2 Generic Captive API 76

4.3 Merchant Manufacturing 77

4.3.1 Merchant Manufacturing by Drug Type 78

4.3.1.1 Branded Merchant API 79

4.3.1.2 Generic Merchant API 80

4.3.2 Merchant Manufacturing by Drug Synthesis 81

4.3.2.1 Merchant Synthetic API 82

4.3.2.2 Merchant Biotech API 83

5 Segmentation of North America Market by Therapeutic Application 84

5.1 Market Overview by Therapeutic Application 84

5.2 Infectious Diseases 86

5.3 Oncology 87

5.4 Ophthalmology 88

5.5 Cardiovascular Disorders 89

5.6 Central Nervous System 90

5.7 Pulmonary Disorders 91

5.8 Orthopedics 92

5.9 Other Applications 93

6 Segmentation of North America Market by Drug Type 94

6.1 Market Overview by Drug Type 94

6.2 Branded Prescription Drugs 96

6.3 Generic Prescription Drugs 97

6.4 OTC Drugs 98

7 North America Market 2021-2028 by Country 99

7.1 Overview of North America Market 99

7.2 U.S. 102

7.3 Canada 113

7.4 Mexico 115

8 Competitive Landscape 117

8.1 Overview of Key Vendors 117

8.2 New Product Launch, Partnership, Investment, and M&A 120

8.3 Company Profiles 121

AbbVie Inc. 121

Astrazeneca 123

Aurobindo Pharma Ltd. 128

BASF 131

Bayer AG 134

Boehringer Ingelheim 138

Catalent Inc. 143

Dr. Reddy's Laboratories 146

F. Hoffmann-La Roche 148

GlaxoSmithKline plc 150

Lonza Group 155

Lupin Limited 160

Merck & Co., Inc. 163

Mylan NV 166

Novartis International AG 169

Pfizer Inc. 172

Sanofi 177

Sun Pharmaceutical Industries Ltd. 180

Teva Pharmaceutical Industries Ltd. 183

Thermo Fisher Scientific 185

9 Investing in North America Market: Risk Assessment and Management 187

9.1 Risk Evaluation of North America Market 187

9.2 Critical Success Factors (CSFs) 190

Related Reports and Products 193

Table 1. Snapshot of North America Active Pharmaceutical Ingredients (API) Market in Balanced Perspective, 2021-2028 19

Table 2. World Economic Outlook, 2021-2031 22

Table 3. World Top 10 Pharmaceutical Companies Based on Projected R&D Spending in 2026, $ bn 37

Table 4. Main Product Trends and Market Opportunities in North America Active Pharmaceutical Ingredients (API) Market 41

Table 5. North America Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 49

Table 6. North America Active Pharmaceutical Ingredients (API) Market: Synthetic API by Drug Type, 2018-2028, $ bn 51

Table 7. North America Active Pharmaceutical Ingredients (API) Market: Biotech API by Drug Type, 2018-2028, $ bn 55

Table 8. North America Active Pharmaceutical Ingredients (API) Market: Biotech API by Category, 2018-2028, $ bn 60

Table 9. North America Active Pharmaceutical Ingredients (API) Market: Biotech API by Expression Technology, 2018-2028, $ bn 63

Table 10. North America Active Pharmaceutical Ingredients (API) Market: HPAPI by Drug Type, 2018-2028, $ bn 69

Table 11. North America Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 72

Table 12. North America Active Pharmaceutical Ingredients (API) Market: Captive Manufacturing by Drug Type, 2018-2028, $ bn 74

Table 13. North America Active Pharmaceutical Ingredients (API) Market: Merchant Manufacturing by Drug Type, 2018-2028, $ bn 78

Table 14. North America Active Pharmaceutical Ingredients (API) Market: Merchant Manufacturing by Drug Synthesis, 2018-2028, $ bn 81

Table 15. North America Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 84

Table 16. North America Active Pharmaceutical Ingredients (API) Market by Drug Type, 2018-2028, $ bn 94

Table 17. North America Active Pharmaceutical Ingredients (API) Market by Country, 2018-2028, $ bn 100

Table 18. U.S. Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 104

Table 19. U.S. Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 104

Table 20. U.S. Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 104

Table 21. Top 15 Countries Supplying API for Medicines Consumed in the US, 2019, % based on Dollar Value 107

Table 22. Canada Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 114

Table 23. Canada Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 114

Table 24. Canada Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 114

Table 25. Mexico Active Pharmaceutical Ingredients (API) Market by Synthesis, 2018-2028, $ bn 116

Table 26. Mexico Active Pharmaceutical Ingredients (API) Market by Manufacturing Process, 2018-2028, $ bn 116

Table 27. Mexico Active Pharmaceutical Ingredients (API) Market by Therapeutic Application, 2018-2028, $ bn 116

Table 28. AbbVie Inc.: Company Snapshot 121

Table 29. AbbVie Inc.: Product Portfolio 121

Table 30. AbbVie Inc.: Revenue, 2018-2020, $ bn 122

Table 31. Astrazeneca: Company Snapshot 123

Table 32. Astrazeneca: Revenue, 2018-2020, $ bn 124

Table 33. Aurobindo Pharma Ltd.: Company Snapshot 128

Table 34. Aurobindo Pharma Ltd.: Product Portfolio 129

Table 35. BASF: Company Snapshot 131

Table 36. BASF: Business Segmentation 132

Table 37. BASF: Revenue by Region 132

Table 38. Bayer AG: Company Snapshot 134

Table 39. Bayer AG: Business Segmentation 135

Table 40. Bayer AG: Revenue, 2018-2020, € bn 135

Table 41. Boehringer Ingelheim: Company Snapshot 138

Table 42. Boehringer Ingelheim: Business Segmentation in 2019 139

Table 43. Boehringer Ingelheim: Product Portfolio 139

Table 44. Boehringer Ingelheim: Revenue, 2018-2020, EUR billion 140

Table 45. Boehringer Ingelheim: Revenue by Region in 2019 140

Table 46. Catalent Inc.: Company Snapshot 143

Table 47. Catalent Inc.: Business Segmentation in 2018 144

Table 48. Catalent Inc.: Product Portfolio 144

Table 49. Catalent Inc.: Revenue, 2018-2020, $ million 145

Table 50. Catalent Inc.: Revenue by Region in 2018 145

Table 51. Dr. Reddy's Laboratories: Company Snapshot 146

Table 52. Dr. Reddy's Laboratories: Business Segmentation 146

Table 53. Dr. Reddy's Laboratories: Revenue, 2019-2021, $ bn 147

Table 54. F. Hoffmann-La Roche: Company Snapshot 148

Table 55. F. Hoffmann-La Roche: Business Segmentation 149

Table 56. GlaxoSmithKline: Company Snapshot 150

Table 57. GlaxoSmithKline: Business Segmentation 151

Table 58. GlaxoSmithKline: Product Portfolio 152

Table 59. GlaxoSmithKline: Revenue, 2018-2020, $ bn 153

Table 60. Lonza Group: Company Snapshot 155

Table 61. Lonza Group: Business Segmentation in 2018 156

Table 62. Lonza Group: Product Portfolio 156

Table 63. Lonza Group: Revenue by Region in 2018 157

Table 64. Lupin Limited: Company Snapshot 160

Table 65. Lupin Limited: Business Segmentation 160

Table 66. Merck & Co., Inc.: Company Snapshot 163

Table 67. Merck & Co., Inc.: Business Segmentation 163

Table 68. Merck & Co., Inc.: Revenue, 2018-2020, $ bn 164

Table 69. Mylan NV: Company Snapshot 166

Table 70. Mylan NV: Revenue, 2017-2019, $ bn 167

Table 71. Novartis International AG: Company Snapshot 169

Table 72. Novartis International AG: Business Segmentation 169

Table 73. Novartis International AG: Revenue, 2017-2019, $ bn 170

Table 74. Pfizer Inc.: Company Snapshot 172

Table 75. Pfizer Inc.: Business Segmentation 173

Table 76. Pfizer Inc.: Product Portfolio 174

Table 77. Pfizer Inc.: Revenue, 2018-2020, $ bn 174

Table 78. Sanofi: Company Snapshot 177

Table 79. Sanofi: Business Segmentation 177

Table 80. Sanofi: Revenue, 2018-2020, $ bn 178

Table 81. Sun Pharmaceutical Industries Limited: Company Snapshot 180

Table 82. Teva Pharmaceutical Industries Ltd.: Company Snapshot 183

Table 83. Teva Pharmaceutical Industries Ltd.: Business Segmentation 184

Table 84. Thermo Fisher Scientific: Company Snapshot 185

Table 85. Risk Evaluation for Investing in North America Market, 2021-2028 188

Table 86. Critical Success Factors and Key Takeaways 191