Global Nimotuzumab Market Growth 2022-2028

1.1 Market Introduction

1.2 Years Considered

1.3 Research Objectives

1.4 Market Research Methodology

1.5 Research Process and Data Source

1.6 Economic Indicators

1.7 Currency Considered

2 Executive Summary

2.1 World Market Overview

2.1.1 Global Nimotuzumab Annual Sales 2017-2028

2.1.2 World Current & Future Analysis for Nimotuzumab by Geographic Region, 2017, 2022 & 2028

2.1.3 World Current & Future Analysis for Nimotuzumab by Country/Region, 2017, 2022 & 2028

2.2 Nimotuzumab Segment by Type

2.2.1 0.5ML

2.2.2 1ML

2.2.3 Other

2.3 Nimotuzumab Sales by Type

2.3.1 Global Nimotuzumab Sales Market Share by Type (2017-2022)

2.3.2 Global Nimotuzumab Revenue and Market Share by Type (2017-2022)

2.3.3 Global Nimotuzumab Sale Price by Type (2017-2022)

2.4 Nimotuzumab Segment by Application

2.4.1 Digestive Tumor

2.4.2 Head And Neck Tumor

2.4.3 Malignant Glioma

2.4.4 Other

2.5 Nimotuzumab Sales by Application

2.5.1 Global Nimotuzumab Sale Market Share by Application (2017-2022)

2.5.2 Global Nimotuzumab Revenue and Market Share by Application (2017-2022)

2.5.3 Global Nimotuzumab Sale Price by Application (2017-2022)

3 Global Nimotuzumab by Company

3.1 Global Nimotuzumab Breakdown Data by Company

3.1.1 Global Nimotuzumab Annual Sales by Company (2020-2022)

3.1.2 Global Nimotuzumab Sales Market Share by Company (2020-2022)

3.2 Global Nimotuzumab Annual Revenue by Company (2020-2022)

3.2.1 Global Nimotuzumab Revenue by Company (2020-2022)

3.2.2 Global Nimotuzumab Revenue Market Share by Company (2020-2022)

3.3 Global Nimotuzumab Sale Price by Company

3.4 Key Manufacturers Nimotuzumab Producing Area Distribution, Sales Area, Product Type

3.4.1 Key Manufacturers Nimotuzumab Product Location Distribution

3.4.2 Players Nimotuzumab Products Offered

3.5 Market Concentration Rate Analysis

3.5.1 Competition Landscape Analysis

3.5.2 Concentration Ratio (CR3, CR5 and CR10) & (2020-2022)

3.6 New Products and Potential Entrants

3.7 Mergers & Acquisitions, Expansion

4 World Historic Review for Nimotuzumab by Geographic Region

4.1 World Historic Nimotuzumab Market Size by Geographic Region (2017-2022)

4.1.1 Global Nimotuzumab Annual Sales by Geographic Region (2017-2022)

4.1.2 Global Nimotuzumab Annual Revenue by Geographic Region

4.2 World Historic Nimotuzumab Market Size by Country/Region (2017-2022)

4.2.1 Global Nimotuzumab Annual Sales by Country/Region (2017-2022)

4.2.2 Global Nimotuzumab Annual Revenue by Country/Region

4.3 Americas Nimotuzumab Sales Growth

4.4 APAC Nimotuzumab Sales Growth

4.5 Europe Nimotuzumab Sales Growth

4.6 Middle East & Africa Nimotuzumab Sales Growth

5 Americas

5.1 Americas Nimotuzumab Sales by Country

5.1.1 Americas Nimotuzumab Sales by Country (2017-2022)

5.1.2 Americas Nimotuzumab Revenue by Country (2017-2022)

5.2 Americas Nimotuzumab Sales by Type

5.3 Americas Nimotuzumab Sales by Application

5.4 United States

5.5 Canada

5.6 Mexico

5.7 Brazil

6 APAC

6.1 APAC Nimotuzumab Sales by Region

6.1.1 APAC Nimotuzumab Sales by Region (2017-2022)

6.1.2 APAC Nimotuzumab Revenue by Region (2017-2022)

6.2 APAC Nimotuzumab Sales by Type

6.3 APAC Nimotuzumab Sales by Application

6.4 China

6.5 Japan

6.6 South Korea

6.7 Southeast Asia

6.8 India

6.9 Australia

6.10 China Taiwan

7 Europe

7.1 Europe Nimotuzumab by Country

7.1.1 Europe Nimotuzumab Sales by Country (2017-2022)

7.1.2 Europe Nimotuzumab Revenue by Country (2017-2022)

7.2 Europe Nimotuzumab Sales by Type

7.3 Europe Nimotuzumab Sales by Application

7.4 Germany

7.5 France

7.6 UK

7.7 Italy

7.8 Russia

8 Middle East & Africa

8.1 Middle East & Africa Nimotuzumab by Country

8.1.1 Middle East & Africa Nimotuzumab Sales by Country (2017-2022)

8.1.2 Middle East & Africa Nimotuzumab Revenue by Country (2017-2022)

8.2 Middle East & Africa Nimotuzumab Sales by Type

8.3 Middle East & Africa Nimotuzumab Sales by Application

8.4 Egypt

8.5 South Africa

8.6 Israel

8.7 Turkey

8.8 GCC Countries

9 Market Drivers, Challenges and Trends

9.1 Market Drivers & Growth Opportunities

9.2 Market Challenges & Risks

9.3 Industry Trends

10 Manufacturing Cost Structure Analysis

10.1 Raw Material and Suppliers

10.2 Manufacturing Cost Structure Analysis of Nimotuzumab

10.3 Manufacturing Process Analysis of Nimotuzumab

10.4 Industry Chain Structure of Nimotuzumab

11 Marketing, Distributors and Customer

11.1 Sales Channel

11.1.1 Direct Channels

11.1.2 Indirect Channels

11.2 Nimotuzumab Distributors

11.3 Nimotuzumab Customer

12 World Forecast Review for Nimotuzumab by Geographic Region

12.1 Global Nimotuzumab Market Size Forecast by Region

12.1.1 Global Nimotuzumab Forecast by Region (2023-2028)

12.1.2 Global Nimotuzumab Annual Revenue Forecast by Region (2023-2028)

12.2 Americas Forecast by Country

12.3 APAC Forecast by Region

12.4 Europe Forecast by Country

12.5 Middle East & Africa Forecast by Country

12.6 Global Nimotuzumab Forecast by Type

12.7 Global Nimotuzumab Forecast by Application

13 Key Players Analysis

13.1 InnoKeys

13.1.1 InnoKeys Company Information

13.1.2 InnoKeys Nimotuzumab Product Offered

13.1.3 InnoKeys Nimotuzumab Sales, Revenue, Price and Gross Margin (2020-2022)

13.1.4 InnoKeys Main Business Overview

13.1.5 InnoKeys Latest Developments

13.2 Roche Diagnostics GmbH

13.2.1 Roche Diagnostics GmbH Company Information

13.2.2 Roche Diagnostics GmbH Nimotuzumab Product Offered

13.2.3 Roche Diagnostics GmbH Nimotuzumab Sales, Revenue, Price and Gross Margin (2020-2022)

13.2.4 Roche Diagnostics GmbH Main Business Overview

13.2.5 Roche Diagnostics GmbH Latest Developments

13.3 Johnson & Johnson

13.3.1 Johnson & Johnson Company Information

13.3.2 Johnson & Johnson Nimotuzumab Product Offered

13.3.3 Johnson & Johnson Nimotuzumab Sales, Revenue, Price and Gross Margin (2020-2022)

13.3.4 Johnson & Johnson Main Business Overview

13.3.5 Johnson & Johnson Latest Developments

13.4 Amgen

13.4.1 Amgen Company Information

13.4.2 Amgen Nimotuzumab Product Offered

13.4.3 Amgen Nimotuzumab Sales, Revenue, Price and Gross Margin (2020-2022)

13.4.4 Amgen Main Business Overview

13.4.5 Amgen Latest Developments

13.5 GSK

13.5.1 GSK Company Information

13.5.2 GSK Nimotuzumab Product Offered

13.5.3 GSK Nimotuzumab Sales, Revenue, Price and Gross Margin (2020-2022)

13.5.4 GSK Main Business Overview

13.5.5 GSK Latest Developments

13.6 Jiangsu Hengrui Pharmaceutical

13.6.1 Jiangsu Hengrui Pharmaceutical Company Information

13.6.2 Jiangsu Hengrui Pharmaceutical Nimotuzumab Product Offered

13.6.3 Jiangsu Hengrui Pharmaceutical Nimotuzumab Sales, Revenue, Price and Gross Margin (2020-2022)

13.6.4 Jiangsu Hengrui Pharmaceutical Main Business Overview

13.6.5 Jiangsu Hengrui Pharmaceutical Latest Developments

14 Research Findings and Conclusion

Table 1. Nimotuzumab Annual Sales CAGR by Geographic Region (2017, 2022 & 2028) & ($ millions)

Table 2. Nimotuzumab Annual Sales CAGR by Country/Region (2017, 2022 & 2028) & ($ millions)

Table 3. Major Players of 0.5ML

Table 4. Major Players of 1ML

Table 5. Major Players of Other

Table 6. Global Nimotuzumab Sales by Type (2017-2022) & (K Units)

Table 7. Global Nimotuzumab Sales Market Share by Type (2017-2022)

Table 8. Global Nimotuzumab Revenue by Type (2017-2022) & ($ million)

Table 9. Global Nimotuzumab Revenue Market Share by Type (2017-2022)

Table 10. Global Nimotuzumab Sale Price by Type (2017-2022) & (US$/Unit)

Table 11. Global Nimotuzumab Sales by Application (2017-2022) & (K Units)

Table 12. Global Nimotuzumab Sales Market Share by Application (2017-2022)

Table 13. Global Nimotuzumab Revenue by Application (2017-2022)

Table 14. Global Nimotuzumab Revenue Market Share by Application (2017-2022)

Table 15. Global Nimotuzumab Sale Price by Application (2017-2022) & (US$/Unit)

Table 16. Global Nimotuzumab Sales by Company (2020-2022) & (K Units)

Table 17. Global Nimotuzumab Sales Market Share by Company (2020-2022)

Table 18. Global Nimotuzumab Revenue by Company (2020-2022) ($ Millions)

Table 19. Global Nimotuzumab Revenue Market Share by Company (2020-2022)

Table 20. Global Nimotuzumab Sale Price by Company (2020-2022) & (US$/Unit)

Table 21. Key Manufacturers Nimotuzumab Producing Area Distribution and Sales Area

Table 22. Players Nimotuzumab Products Offered

Table 23. Nimotuzumab Concentration Ratio (CR3, CR5 and CR10) & (2020-2022)

Table 24. New Products and Potential Entrants

Table 25. Mergers & Acquisitions, Expansion

Table 26. Global Nimotuzumab Sales by Geographic Region (2017-2022) & (K Units)

Table 27. Global Nimotuzumab Sales Market Share Geographic Region (2017-2022)

Table 28. Global Nimotuzumab Revenue by Geographic Region (2017-2022) & ($ millions)

Table 29. Global Nimotuzumab Revenue Market Share by Geographic Region (2017-2022)

Table 30. Global Nimotuzumab Sales by Country/Region (2017-2022) & (K Units)

Table 31. Global Nimotuzumab Sales Market Share by Country/Region (2017-2022)

Table 32. Global Nimotuzumab Revenue by Country/Region (2017-2022) & ($ millions)

Table 33. Global Nimotuzumab Revenue Market Share by Country/Region (2017-2022)

Table 34. Americas Nimotuzumab Sales by Country (2017-2022) & (K Units)

Table 35. Americas Nimotuzumab Sales Market Share by Country (2017-2022)

Table 36. Americas Nimotuzumab Revenue by Country (2017-2022) & ($ Millions)

Table 37. Americas Nimotuzumab Revenue Market Share by Country (2017-2022)

Table 38. Americas Nimotuzumab Sales by Type (2017-2022) & (K Units)

Table 39. Americas Nimotuzumab Sales Market Share by Type (2017-2022)

Table 40. Americas Nimotuzumab Sales by Application (2017-2022) & (K Units)

Table 41. Americas Nimotuzumab Sales Market Share by Application (2017-2022)

Table 42. APAC Nimotuzumab Sales by Region (2017-2022) & (K Units)

Table 43. APAC Nimotuzumab Sales Market Share by Region (2017-2022)

Table 44. APAC Nimotuzumab Revenue by Region (2017-2022) & ($ Millions)

Table 45. APAC Nimotuzumab Revenue Market Share by Region (2017-2022)

Table 46. APAC Nimotuzumab Sales by Type (2017-2022) & (K Units)

Table 47. APAC Nimotuzumab Sales Market Share by Type (2017-2022)

Table 48. APAC Nimotuzumab Sales by Application (2017-2022) & (K Units)

Table 49. APAC Nimotuzumab Sales Market Share by Application (2017-2022)

Table 50. Europe Nimotuzumab Sales by Country (2017-2022) & (K Units)

Table 51. Europe Nimotuzumab Sales Market Share by Country (2017-2022)

Table 52. Europe Nimotuzumab Revenue by Country (2017-2022) & ($ Millions)

Table 53. Europe Nimotuzumab Revenue Market Share by Country (2017-2022)

Table 54. Europe Nimotuzumab Sales by Type (2017-2022) & (K Units)

Table 55. Europe Nimotuzumab Sales Market Share by Type (2017-2022)

Table 56. Europe Nimotuzumab Sales by Application (2017-2022) & (K Units)

Table 57. Europe Nimotuzumab Sales Market Share by Application (2017-2022)

Table 58. Middle East & Africa Nimotuzumab Sales by Country (2017-2022) & (K Units)

Table 59. Middle East & Africa Nimotuzumab Sales Market Share by Country (2017-2022)

Table 60. Middle East & Africa Nimotuzumab Revenue by Country (2017-2022) & ($ Millions)

Table 61. Middle East & Africa Nimotuzumab Revenue Market Share by Country (2017-2022)

Table 62. Middle East & Africa Nimotuzumab Sales by Type (2017-2022) & (K Units)

Table 63. Middle East & Africa Nimotuzumab Sales Market Share by Type (2017-2022)

Table 64. Middle East & Africa Nimotuzumab Sales by Application (2017-2022) & (K Units)

Table 65. Middle East & Africa Nimotuzumab Sales Market Share by Application (2017-2022)

Table 66. Key Market Drivers & Growth Opportunities of Nimotuzumab

Table 67. Key Market Challenges & Risks of Nimotuzumab

Table 68. Key Industry Trends of Nimotuzumab

Table 69. Nimotuzumab Raw Material

Table 70. Key Suppliers of Raw Materials

Table 71. Nimotuzumab Distributors List

Table 72. Nimotuzumab Customer List

Table 73. Global Nimotuzumab Sales Forecast by Region (2023-2028) & (K Units)

Table 74. Global Nimotuzumab Sales Market Forecast by Region

Table 75. Global Nimotuzumab Revenue Forecast by Region (2023-2028) & ($ millions)

Table 76. Global Nimotuzumab Revenue Market Share Forecast by Region (2023-2028)

Table 77. Americas Nimotuzumab Sales Forecast by Country (2023-2028) & (K Units)

Table 78. Americas Nimotuzumab Revenue Forecast by Country (2023-2028) & ($ millions)

Table 79. APAC Nimotuzumab Sales Forecast by Region (2023-2028) & (K Units)

Table 80. APAC Nimotuzumab Revenue Forecast by Region (2023-2028) & ($ millions)

Table 81. Europe Nimotuzumab Sales Forecast by Country (2023-2028) & (K Units)

Table 82. Europe Nimotuzumab Revenue Forecast by Country (2023-2028) & ($ millions)

Table 83. Middle East & Africa Nimotuzumab Sales Forecast by Country (2023-2028) & (K Units)

Table 84. Middle East & Africa Nimotuzumab Revenue Forecast by Country (2023-2028) & ($ millions)

Table 85. Global Nimotuzumab Sales Forecast by Type (2023-2028) & (K Units)

Table 86. Global Nimotuzumab Sales Market Share Forecast by Type (2023-2028)

Table 87. Global Nimotuzumab Revenue Forecast by Type (2023-2028) & ($ Millions)

Table 88. Global Nimotuzumab Revenue Market Share Forecast by Type (2023-2028)

Table 89. Global Nimotuzumab Sales Forecast by Application (2023-2028) & (K Units)

Table 90. Global Nimotuzumab Sales Market Share Forecast by Application (2023-2028)

Table 91. Global Nimotuzumab Revenue Forecast by Application (2023-2028) & ($ Millions)

Table 92. Global Nimotuzumab Revenue Market Share Forecast by Application (2023-2028)

Table 93. InnoKeys Basic Information, Nimotuzumab Manufacturing Base, Sales Area and Its Competitors

Table 94. InnoKeys Nimotuzumab Product Offered

Table 95. InnoKeys Nimotuzumab Sales (K Units), Revenue ($ Million), Price (US$/Unit) and Gross Margin (2020-2022)

Table 96. InnoKeys Main Business

Table 97. InnoKeys Latest Developments

Table 98. Roche Diagnostics GmbH Basic Information, Nimotuzumab Manufacturing Base, Sales Area and Its Competitors

Table 99. Roche Diagnostics GmbH Nimotuzumab Product Offered

Table 100. Roche Diagnostics GmbH Nimotuzumab Sales (K Units), Revenue ($ Million), Price (US$/Unit) and Gross Margin (2020-2022)

Table 101. Roche Diagnostics GmbH Main Business

Table 102. Roche Diagnostics GmbH Latest Developments

Table 103. Johnson & Johnson Basic Information, Nimotuzumab Manufacturing Base, Sales Area and Its Competitors

Table 104. Johnson & Johnson Nimotuzumab Product Offered

Table 105. Johnson & Johnson Nimotuzumab Sales (K Units), Revenue ($ Million), Price (US$/Unit) and Gross Margin (2020-2022)

Table 106. Johnson & Johnson Main Business

Table 107. Johnson & Johnson Latest Developments

Table 108. Amgen Basic Information, Nimotuzumab Manufacturing Base, Sales Area and Its Competitors

Table 109. Amgen Nimotuzumab Product Offered

Table 110. Amgen Nimotuzumab Sales (K Units), Revenue ($ Million), Price (US$/Unit) and Gross Margin (2020-2022)

Table 111. Amgen Main Business

Table 112. Amgen Latest Developments

Table 113. GSK Basic Information, Nimotuzumab Manufacturing Base, Sales Area and Its Competitors

Table 114. GSK Nimotuzumab Product Offered

Table 115. GSK Nimotuzumab Sales (K Units), Revenue ($ Million), Price (US$/Unit) and Gross Margin (2020-2022)

Table 116. GSK Main Business

Table 117. GSK Latest Developments

Table 118. Jiangsu Hengrui Pharmaceutical Basic Information, Nimotuzumab Manufacturing Base, Sales Area and Its Competitors

Table 119. Jiangsu Hengrui Pharmaceutical Nimotuzumab Product Offered

Table 120. Jiangsu Hengrui Pharmaceutical Nimotuzumab Sales (K Units), Revenue ($ Million), Price (US$/Unit) and Gross Margin (2020-2022)

Table 121. Jiangsu Hengrui Pharmaceutical Main Business

Table 122. Jiangsu Hengrui Pharmaceutical Latest Developments

List of Figures

Figure 1. Picture of Nimotuzumab

Figure 2. Nimotuzumab Report Years Considered

Figure 3. Research Objectives

Figure 4. Research Methodology

Figure 5. Research Process and Data Source

Figure 6. Global Nimotuzumab Sales Growth Rate 2017-2028 (K Units)

Figure 7. Global Nimotuzumab Revenue Growth Rate 2017-2028 ($ Millions)

Figure 8. Nimotuzumab Sales by Region (2021 & 2028) & ($ millions)

Figure 9. Product Picture of 0.5ML

Figure 10. Product Picture of 1ML

Figure 11. Product Picture of Other

Figure 12. Global Nimotuzumab Sales Market Share by Type in 2021

Figure 13. Global Nimotuzumab Revenue Market Share by Type (2017-2022)

Figure 14. Nimotuzumab Consumed in Digestive Tumor

Figure 15. Global Nimotuzumab Market: Digestive Tumor (2017-2022) & (K Units)

Figure 16. Nimotuzumab Consumed in Head And Neck Tumor

Figure 17. Global Nimotuzumab Market: Head And Neck Tumor (2017-2022) & (K Units)

Figure 18. Nimotuzumab Consumed in Malignant Glioma

Figure 19. Global Nimotuzumab Market: Malignant Glioma (2017-2022) & (K Units)

Figure 20. Nimotuzumab Consumed in Other

Figure 21. Global Nimotuzumab Market: Other (2017-2022) & (K Units)

Figure 22. Global Nimotuzumab Sales Market Share by Application (2017-2022)

Figure 23. Global Nimotuzumab Revenue Market Share by Application in 2021

Figure 24. Nimotuzumab Revenue Market by Company in 2021 ($ Million)

Figure 25. Global Nimotuzumab Revenue Market Share by Company in 2021

Figure 26. Global Nimotuzumab Sales Market Share by Geographic Region (2017-2022)

Figure 27. Global Nimotuzumab Revenue Market Share by Geographic Region in 2021

Figure 28. Global Nimotuzumab Sales Market Share by Region (2017-2022)

Figure 29. Global Nimotuzumab Revenue Market Share by Country/Region in 2021

Figure 30. Americas Nimotuzumab Sales 2017-2022 (K Units)

Figure 31. Americas Nimotuzumab Revenue 2017-2022 ($ Millions)

Figure 32. APAC Nimotuzumab Sales 2017-2022 (K Units)

Figure 33. APAC Nimotuzumab Revenue 2017-2022 ($ Millions)

Figure 34. Europe Nimotuzumab Sales 2017-2022 (K Units)

Figure 35. Europe Nimotuzumab Revenue 2017-2022 ($ Millions)

Figure 36. Middle East & Africa Nimotuzumab Sales 2017-2022 (K Units)

Figure 37. Middle East & Africa Nimotuzumab Revenue 2017-2022 ($ Millions)

Figure 38. Americas Nimotuzumab Sales Market Share by Country in 2021

Figure 39. Americas Nimotuzumab Revenue Market Share by Country in 2021

Figure 40. United States Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 41. Canada Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 42. Mexico Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 43. Brazil Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 44. APAC Nimotuzumab Sales Market Share by Region in 2021

Figure 45. APAC Nimotuzumab Revenue Market Share by Regions in 2021

Figure 46. China Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 47. Japan Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 48. South Korea Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 49. Southeast Asia Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 50. India Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 51. Australia Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 52. Europe Nimotuzumab Sales Market Share by Country in 2021

Figure 53. Europe Nimotuzumab Revenue Market Share by Country in 2021

Figure 54. Germany Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 55. France Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 56. UK Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 57. Italy Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 58. Russia Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 59. Middle East & Africa Nimotuzumab Sales Market Share by Country in 2021

Figure 60. Middle East & Africa Nimotuzumab Revenue Market Share by Country in 2021

Figure 61. Egypt Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 62. South Africa Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 63. Israel Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 64. Turkey Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 65. GCC Country Nimotuzumab Revenue Growth 2017-2022 ($ Millions)

Figure 66. Manufacturing Cost Structure Analysis of Nimotuzumab in 2021

Figure 67. Manufacturing Process Analysis of Nimotuzumab

Figure 68. Industry Chain Structure of Nimotuzumab

Figure 69. Channels of Distribution

Figure 70. Distributors Profiles